Protein: ENSP00000384152
Gene: TBX5

LinkedOmicsKB © 2022-2023 Zhang Lab

TBX5:
T-box transcription factor 5

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S38ALGAPSKSPSSPQAA219----------5554------
S40GAPSKSPSSPQAAFT245----------191754------
S41APSKSPSSPQAAFTQ43896-----27---847710194------
S346KKPYMETSPSEEDSF243----------991213------
S367QQQGLGASYRTESAQ158----------2929--------
T481TGLQSPGTLQPPEFL128----------1414--------
Showing 1 to 6 of 6 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S38ALGAPSKSPSSPQAA-----------
S40GAPSKSPSSPQAAFT-----------
S41APSKSPSSPQAAFTQ-2.6e-53------1.1e-24-1.7e-30---
S346KKPYMETSPSEEDSF-----------
S367QQQGLGASYRTESAQ-4.6e-14------4.5e-14----
T481TGLQSPGTLQPPEFL-----------
Showing 1 to 6 of 6 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_COAGULATIONT4812.2e-16-----2.2e-16----
xcell: Endothelial cellS413.9e-5---0.52-1.6e-46.8e-3---
xcell: stroma scoreS416.1e-4---0.5-4.4e-70.83---
PROGENy: WNTS417.6e-4---0.19-0.070.007---
ESTIMATE: ESTIMATEScoreT4819.1e-4-----9.1e-4----
HALLMARK_IL2_STAT5_SIGNALINGT4810.001-----0.001----
xcell: Endothelial cellT4810.001-----0.001----
xcell: NeutrophilS413.3e-3---0.2-0.170.015---
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONS413.8e-3----0.61-4.8e-40.042---
HALLMARK_TNFA_SIGNALING_VIA_NFKBS413.8e-3----0.55-0.0191.1e-3---
Showing 1 to 10 of 1548 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS38S40S41S346S367T481proteinRNASCNVmethylationCCRCCS38S40S41S346S367T481proteinRNASCNVmethylationCOADS38S40S41S346S367T481proteinRNASCNVmethylationGBMS38S40S41S346S367T481proteinRNASCNVmethylationHNSCCS38S40S41S346S367T481proteinRNASCNVmethylationLSCCS38S40S41S346S367T481proteinRNASCNVmethylationLUADS38S40S41S346S367T481proteinRNASCNVmethylationOVS38S40S41S346S367T481proteinRNASCNVmethylationPDACS38S40S41S346S367T481proteinRNASCNVmethylationUCECS38S40S41S346S367T481proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
SNRKS416.2e-6---0.19-1.8e-45.4e-3---
TEKS418.2e-6-----7.8e-43.2e-3---
TNIKT4813.4e-5-----3.4e-5----
MAP3K3S415.3e-5---0.16-1.9e-30.013---
IRAK3S417.0e-5---2.8e-3-0.0370.069---
KITS411.1e-4---0.048-8.4e-30.038---
NEK3S412.1e-4---3.3e-3-0.010.36---
TGFBR2S412.2e-4-----1.7e-30.036---
AKT3S412.5e-4---0.4-2.1e-30.016---
MAPKAPK5S412.8e-4---2.1e-4-0.380.086---
Showing 1 to 10 of 3228 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PLPP2S41-4.8e-4------5.2e-4-0.14---
PPP4CS41-5.2e-4----0.41--0.001-0.055---
CTDSPL2T481-5.4e-4------5.4e-4----
EYA2S40-8.8e-4------8.8e-4----
PDP1S41-1.9e-3----0.23--0.01-0.11---
TIMM50S40-2.1e-3------2.1e-3----
IMPAD1S346-3.2e-3-------3.2e-3---
IMPA2S40-3.7e-3------3.7e-3----
SGPP2S41-5.9e-3------0.1-0.023---
PTPRAS40-0.006------0.006----
Showing 1 to 10 of 1440 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.