Basic information
- Full name
- polynucleotide kinase 3'-phosphatase
- Ensembl
- ENSG00000039650.12
- Summary
- This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]
- Annotation
- Essential genes Phosphatase
Protein product
- ENST00000322344.8 Primary ENSP00000323511.2 (8 phosphosites)
- ENST00000596014.5
- ENST00000600573.5
- ENST00000631020.2
- ENST00000600910.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 4.2e-7 | - | -0.047 | - | - | 4.8e-4 | 8.2e-7 | 3.8e-6 | - | 0.79 | - |
protein | 6.6e-20 | - | -0.23 | 6.7e-13 | - | 0.39 | 1.7e-21 | 1.4e-10 | 3.3e-4 | -0.75 | -0.83 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of PNKP with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_G2M_CHECKPOINT | 6.7e-7 | -0.28 | 0.16 | 0.37 | 5.6e-4 | 3.5e-4 | 0.63 | 2.2e-4 | -0.5 | 0.75 | 2.4e-4 | |
HALLMARK_E2F_TARGETS | 1.1e-6 | -0.48 | 0.26 | 0.43 | 8.2e-4 | 7.1e-5 | 0.46 | 2.8e-4 | -0.45 | 0.95 | 1.2e-3 | |
KINASE-PSP_CDK2 | 2.4e-6 | -0.084 | 0.31 | 4.5e-3 | 7.9e-3 | 2.3e-3 | 0.33 | 0.011 | -0.97 | 0.91 | 4.6e-4 | |
KINASE-PSP_CK2A1/CSNK2A1 | 2.5e-6 | -0.36 | 0.5 | 0.089 | 1.0e-4 | 0.025 | 0.14 | 0.28 | 2.8e-3 | -0.71 | 0.034 | |
HALLMARK_MITOTIC_SPINDLE | 2.2e-5 | -0.12 | 0.22 | 0.94 | 7.4e-3 | 0.24 | 0.33 | 7.8e-5 | 0.093 | 0.88 | 2.2e-3 | |
mutation burden | 7.6e-5 | -0.15 | 0.049 | -0.98 | 0.22 | 2.6e-3 | 0.55 | 8.0e-4 | 0.57 | 0.34 | 0.022 | |
HALLMARK_MYC_TARGETS_V2 | 5.0e-4 | -0.16 | 0.8 | 0.5 | 1.1e-3 | 0.22 | 0.35 | 0.017 | 0.62 | 0.66 | 6.4e-3 | |
HALLMARK_SPERMATOGENESIS | 7.2e-4 | 0.73 | 0.65 | 0.26 | -0.97 | 1.1e-6 | 0.14 | 2.3e-3 | -0.82 | -0.037 | 0.089 | |
SBS4 (smoking) | 7.5e-4 | - | - | - | - | 0.036 | 0.5 | 2.1e-3 | - | - | - | |
chromosomal instability | 8.0e-4 | 0.47 | 0.07 | 0.25 | 0.27 | 1.5e-3 | 0.12 | 0.21 | -0.38 | 0.077 | -0.28 |
Cis-association
Associations between omics data of PNKP
Trans-association
Associations of the protein abundance of PNKP and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.