Basic information

Full name
protein tyrosine phosphatase non-receptor type 1
Ensembl
ENSG00000196396.10
Summary
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Annotation
Druggable target (Tier T3) Phosphatase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.38-5.2e-5--2.1e-13-1.9e-20-8.7e-25-2.3e-3-
protein1.5e-44-1.7e-141.8e-20-5.8e-241.2e-8-0.0450.125.3e-120.7

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8.599.51010.51111.51212.51313.514log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC24.52525.52626.52727.52828.529log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618200-2-4-6-8-10-12-14-16-18-20Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PTPN1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_IL6_JAK_STAT3_SIGNALING1e-340.043.6e-78.8e-31.3e-61.1e-33.6e-50.0182.1e-52.7e-62.8e-8
HALLMARK_INFLAMMATORY_RESPONSE5.2e-320.178.0e-60.0032.8e-66.4e-55.5e-40.0897.6e-51.1e-71.1e-7
HALLMARK_ALLOGRAFT_REJECTION7.7e-320.0216.9e-60.0153.7e-62.2e-41.0e-40.0111.0e-45.4e-47e-9
HALLMARK_INTERFERON_GAMMA_RESPONSE2.4e-300.024.7e-65.9e-31.3e-42.0e-41.9e-50.0611.5e-50.012.8e-9
xcell: Macrophage M12.6e-301.2e-31e-70.363.6e-40.0141.3e-54.3e-36.2e-79.5e-34e-9
xcell: immune score2.1e-297.2e-48.6e-100.532.7e-44.3e-43.6e-50.0275.3e-42.6e-34.6e-8
xcell: Macrophage1.5e-281.9e-36.4e-90.295.1e-40.0827.5e-50.0476.7e-67.9e-41.4e-9
ESTIMATE: ImmuneScore1.2e-250.0271.5e-40.0849.2e-57.7e-45.5e-50.0651.2e-42.1e-31.2e-7
xcell: B cell4.5e-257.0e-51.0e-60.895.7e-31.7e-41.7e-56.5e-46.8e-30.0151.4e-5
HALLMARK_COMPLEMENT4.9e-250.127.7e-70.012.2e-52.2e-35.4e-50.222.0e-57.7e-33.9e-5
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PTPN1

BRCA0.690.450.47proteinmRNASCNVmethylationCCRCC0.62-0.070.390.060.38-0.12proteinmRNASCNVmethylationCOAD0.610.380.62proteinmRNASCNVmethylationGBM0.690.090.28-0.010.340.08proteinmRNASCNVmethylationHNSCC0.71-0.030.41-0.040.54-0.16proteinmRNASCNVmethylationLSCC0.70-0.090.34-0.040.37-0.07proteinmRNASCNVmethylationLUAD0.62-0.080.32-0.220.44-0.16proteinmRNASCNVmethylationOV0.410.020.38proteinmRNASCNVmethylationPDAC0.59-0.020.220.130.20-0.02proteinmRNASCNVmethylationUCEC0.710.150.440.010.430.03proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PTPN1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.