Basic information
- Phenotype
- xcell: T cell CD8+ effector memory
- Description
- Enrichment score inferring the proportion of effector memory CD8+ T cells in the tumor derived from RNA data using the xCell tool.
- Source
- https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1349-1
- Method
- The R package immunedeconv (V2.0.4) (PMID: 31510660) was used to perform immune cell deconvolution using RNA expression data (TPM).
- Genes
-
- ABCD2
- ABCF1
- ABCF3
- ABT1
- ACADVL
- ACTR1B
- ADAT1
- AHNAK
- ALKBH4
- AMBRA1
- ANAPC2
- ANGEL2
- ARFRP1
- ARHGEF1
- ARHGEF5
- ARPC5L
- ASTE1
- ATR
- B4GALT3
- BIN2
- BIN3
- BMPR1A
- BTN2A1
- C1orf35
- C2orf42
- C7orf26
- C8G
- CACNB1
- CALM1
- CAPN10
- CAPN2
- CAPZB
- CASP8
- CCDC130
- CCDC85C
- CCL4
- CCR5
- CD160
- CD2
- CD300A
- CD3D
- CD3E
- CD3G
- CD7
- CD8A
- CD8B
- CD96
- CDC14A
- CDK10
- CDKN2AIP
- CEP250
- CHD8
- CHST12
- CIAO1
- CNNM2
- COL5A3
- COLQ
- COPB1
- CORO7
- CREBZF
- CROCC
- CRTAM
- CSNK1G2
- CSTF2T
- CTBP1
- CTDSP1
- CTR9
- CTSW
- CX3CR1
- CXCR3
- CXCR6
- CYTH4
- DAXX
- DDX18
- DEFB126
- DHX16
- DHX8
- DIAPH1
- DIDO1
- DLEC1
- DMWD
- DNAJB1
- DNAJC24
- DPP8
- DUSP8
- DYNC1H1
- DYNLT1
- E4F1
- ELK4
- ELP3
- EMD
- ERAL1
- ERN1
- EXOC2
- FASLG
- FBXO3
- FBXO31
- FBXW4
- FLT4
- FYCO1
- GCC1
- GIMAP4
- GIMAP6
- GIPR
- GNLY
- GOLGA1
- GOLGA4
- GPKOW
- GPR171
- GPR52
- GPR65
- GPR68
- GRAP2
- GSDMD
- GTF3C1
- GYG1
- GZMA
- GZMB
- GZMH
- GZMK
- GZMM
- HAUS3
- HIVEP3
- HLA-A
- HLCS
- HMGN4
- HMGXB3
- HMOX2
- IDH3B
- IFNG
- IKZF3
- IL10RA
- IL12RB1
- IL18RAP
- IL2RB
- IMP3
- INPP5E
- IRF3
- ITGAL
- JMJD6
- KIAA1109
- KIF22
- KLHDC4
- KLHL11
- KLRB1
- KLRD1
- KLRG1
- KRI1
- LAG3
- LAIR2
- LIPT1
- LTB4R2
- LTK
- LZTR1
- MAML1
- MAN2C1
- MAP3K10
- MAP7D1
- MAPK13
- MARK3
- MDN1
- MEN1
- MKNK1
- MRFAP1L1
- MRPL22
- MRPS22
- MSH3
- MT2A
- MTO1
- MUS81
- MYO1F
- N4BP1
- NCR1
- NCR3
- NDUFB1
- NDUFB2
- NDUFS6
- NKG7
- NMUR1
- NOL6
- NPRL2
- NRBP1
- OSBPL7
- OTOF
- OTUD7B
- PABPC3
- PANK4
- PAPOLG
- PCNT
- PDCD1
- PHKG2
- PLCG1
- PLXDC1
- PMS1
- PNMA3
- POLG
- PPP1CA
- PPP2R5C
- PRDM8
- PREB
- PRF1
- PRKG2
- PRMT7
- PSMC5
- PSME1
- PSTPIP1
- PTGDR
- PTPN4
- PTPRA
- PTPRC
- PTPRCAP
- PUF60
- PURA
- PVRIG
- PWWP2A
- PYHIN1
- PZP
- RBL2
- RFX1
- RGS1
- RGS9
- RHOG
- RHOT2
- RIC8A
- RIPK1
- RNF113A
- RNF126
- RNF167
- RNF25
- RPN2
- RPUSD2
- RWDD1
- S100B
- SACM1L
- SART3
- SASH3
- SBF1
- SCAP
- SEC16A
- SEC24C
- SF3A1
- SF3B2
- SGSM2
- SH2D1A
- SIT1
- SLAMF1
- SLC1A7
- SLC25A12
- SLC25A20
- SLC35B1
- SLC38A1
- SNRNP200
- SNTB2
- SPSB3
- SRCAP
- SRRT
- SSR2
- STK25
- STUB1
- STX18
- STX4
- TAF10
- TBCC
- TBX21
- TCOF1
- TIMM22
- TMEM184B
- TNIP2
- TRAF3IP3
- TRAPPC4
- TRMT2A
- TRMU
- TRNAU1AP
- TTC22
- TUFM
- TULP4
- UBE2Q1
- UBN1
- UBTF
- URB2
- URGCP
- USP1
- USP34
- USP47
- VPS4A
- WAS
- WDR82
- WSB2
- WWP2
- XCL1
- ZAP70
- ZBTB1
- ZBTB39
- ZMYM1
- ZNF142
- ZNF276
- ZNF335
- ZNF394
- ZNF428
- ZNF549
- ZNF639
- ZNF696
- ZNF79
- More...
Gene association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in bar plots. The scatter plot highlights significant associations diven by protein rather than mRNA abundance.
Association of protein abundance of genes
Signed p-values | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
| No matching records found | ||||||||||||
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with xcell: T cell CD8+ effector memory to WebGestalt.
Phosphosite association
Number of significant genes with P-value ≤ 10-6 for each cohorts are summarized in the bar plot. The scatter plot highlights significant associations diven by phosphorylation rather than protein abundance.
Signed p-values | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Protein | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
| No matching records found | |||||||||||||
Gene set enrichment analysis
Submit phosphorylation sites and the common logarithm of the p-values of their association with xcell: T cell CD8+ effector memory to WebGestalt.